Historical Grants
UMDF Historical Research Grants
| Year | Project Title | Type of Award | Investigator | Institution | Country | Total Amount Funded by UMDF | Co-Funded by: |
|---|---|---|---|---|---|---|---|
| 1998 | "Mitochondrial etiologies of pseudoobstruction and dysmotility in children" | Principal Investigator Grant | Carolyn Bay | Children's Hospital of Pittsburgh | US | $5,000.00 | |
| 1998 | "Gene mutations in Leigh's Disease" | Principal Investigator Grant | John Shoffner | Horizon Molecular Laboratory | US | $30,000.00 | |
| 1998 | "Search for Pathogenic Mitochondrial DNA Mutations Using Temporal Temperature Gradient Gel Electrophoresis (TTGE)" | Principal Investigator Grant | Richard Boles | Children's Hospital of Los Angeles | US | $30,000.00 | |
| 1999 | "Efficacy of Prenatal Diagnosis of Mitochondrial Diseases" | Principal Investigator Grant | Brian Robinson | The Hospital for Sick Children | CA | $8,863.00 | |
| 1999 | "Characterization of Mitochondrial Nitric-Oxide Synthase" | Principal Investigator Grant | Cecilia Giulivi | University of Minnesota | US | $31,137.00 | |
| 2000 | "Quantitative In Vivo 1H Magnetic Resonance Spectroscopic Imaging of Cerebral Lactate as a Screening Test for Mitochondrial Disorders" | Principal Investigator Grant | Dikoma Shungu | Columbia University | US | $36,719.00 | |
| 2000 | "Is oxidative damage a result of metabolic abnormalities in Alzheimer disease?" | Principal Investigator Grant | George Perry | Case Western Reserve University | US | $18,281.00 | |
| 2001 | "Efficacy of prenatal diagnosis of mitochondrial diseases." | Principal Investigator Grant | Brian Robinson | The Hospital for Sick Children | CA | $15,000.00 | |
| 2001 | "Complex I: The role of nuclear genes in disorders of childhood due to mitochondrial Complex I deficiency." | Principal Investigator Grant | Edwin Kirk | Sydney Children's Hospital | AU | $12,000.00 | |
| 2001 | "Biochemical Basis for Maternally Inherited Deafness" | Principal Investigator Grant | Min-Xin Guan | Children's Hospital Medical Center | US | $33,000.00 | |
| 2002 | "Transport diseases in mitochondria: Full screening of DNA alterations in human genes encoding TOMM and TIMM complexes in patients with mitochondrial diseases" | Principal Investigator Grant | Jose Hernandez-Yago | Institute for Cell Research | ES | $41,085.00 | |
| 2002 | "Electrophysiologic Properties of Neural Stem Cells from Patients with Mitochondrial Disease" | Principal Investigator Grant | Philip Schwartz | Children's Hospital of Orange County | US | $81,574.00 | |
| 2002 | "Exercise-induced mitochondrial gene shifting: Resistance training as a therapy for sporadic mtDNA mutations" | Principal Investigator Grant | Tanja Taivassalo | Institute for Exercise & Environmental Medicine | US | $61,389.00 | |
| 2002 | "Exploiting the potential of yeast NDI1 gene in the therapy of diseases linked with mtDNA" | Principal Investigator Grant | Yidong Bai | University of Texas Health Science Center at San Antonio | US | $66,000.00 | |
| 2003 | "The Use of the Yeast CYB2 Gene As Therapy for Complex I Mutations in a C. elegans Model System" | Principal Investigator Grant | Bernard Lemire | University of Alberta | CA | $76,780.00 | |
| 2003 | "MtDNA complementation and recombination in mitochondrial disorders" | Principal Investigator Grant | Giovanni Manfredi | Weill Medical College of Cornell University | US | $50,000.00 | |
| 2003 | "Application of RNA interference in the study of NADH-ubiquinone oxidoreductase (complex I) assembly in mammalian mitochondria" | Principal Investigator Grant | Immo Scheffler | University of California, San Diego | US | $100,000.00 | |
| 2003 | "Molecular Basis of Mitochondrial Membrane Dynamics: a New Paradigm of Human Disease" | Principal Investigator Grant | Koji Okamoto | University of Utah | US | $83,400.00 | |
| 2003 | "Role of Rhomboid Proteolysis in Optic Atrophy" | Principal Investigator Grant | Matthew Freeman | Laboratory of Molecular Biology ? M.R.C. | UK | $90,000.00 | |
| 2003 | "Selective Elimination of Defective Mitochondrial Genomes as an Approach to the Reversal of NARP and MILS Syndromes, Heritable Mitochondrial Disorders" | Principal Investigator Grant | Mikhail Alexeyev | University of South Alabama | US | $100,000.00 | |
| 2004 | "Drug development for the regulation of respiratory chain components in mitochondria" | Principal Investigator Grant | Brian Robinson | Hospital for Sick Children | CA | $44,000.00 | |
| 2004 | "Understanding the role of mitochondrial fusion in mitochondrial myopathies" | Principal Investigator Grant | David C. Chan | California Institute of Technology | US | $128,000.00 | |
| 2004 | "GSH levels, reactive oxygen species production, lipid peroxidation, products and mitochondrial membrane potential in patients with mitochondrial disease" | Principal Investigator Grant | Gregory M. Enns | Stanford University | US | $34,179.00 | |
| 2004 | "The hypoxia sensing transcription factor EPAS1/HIF-2a is a novel mitochondrial disease candidate in mice and man" | Principal Investigator Grant | Joseph A. Garcia | University of Texas SW Medical Center at Dallas | US | $88,852.00 | |
| 2004 | "The nuclear-encoded gene OMI and mitochondrial disease" | Principal Investigator Grant | Miriam H. Meisler | University of Michigan | US | $108,305.00 | |
| 2004 | "Restoration of thymidine phosphorylase activity in MNGIE patients through platelets infusion" | Principal Investigator Grant | Ramon Marti | Fundacio Institut Hospital Vall d'Hebron | ES | $33,776.00 | |
| 2004 | "Protein phosphatase 2A in mitochondrial function and disease" | Principal Investigator Grant | Stefan Strack | University of Iowa, Carver College of Medicine | US | $88,000.00 | |
| 2004 | "Genomic Approaches to Human Cytochrome c Oxidase Deficiency" | Principal Investigator Grant | Vamsi K. Mootha | Broad Institute, Massachusetts Institute of Technology | US | $90,200.00 | |
| 2004 | "Development of a method for transforming mitochondria in living mammalian cells with exogenous DNA" | Principal Investigator Grant | Volkmar Weissig | Northeastern University, Dept. of Pharmaceutical Sciences | US | $99,360.00 | |
| 2005 | "The Mechanism of Mitochondrial Dysfunction in Paraplegin-Deficient Mice." | Principal Investigator Grant | Elena Rugarli | Telethon Institute of Genetics and Medicine | IT | $126,500.00 | |
| 2005 | "The assembly pathway of human cytochrome-c oxidase studied with RNA interference" | Principal Investigator Grant | Jan-Willem Taanman | University College London | UK | $86,445.00 | |
| 2005 | "Biochemical and structural studies on mitochondrial disease mutations in methionyl-tRNA." | Principal Investigator Grant | Linda Spremulli | University of North Carolina, Chapel Hill | US | $110,980.00 | |
| 2005 | "Role of mitofusin-2, a mitochondria-shaping protein mutated in Charcot-Marie-Tooth IIa, in controlling mitochondrial function and apoptosis." | Principal Investigator Grant | Luca Scorrano | Dulbecco-Telethon Institute | IT | $94,000.00 | |
| 2005 | "Molecular Basis of Mitochondrial Gene Regulation" | Principal Investigator Grant | Mair Churchill | University of Colorado Health Sciences Center | US | $116,133.00 | |
| 2005 | "MitoPLD, a novel enzymatic regulator of mitochondrial morphology and fusion" | Principal Investigator Grant | Michael Frohman | Stony Brook University | US | $141,027.00 | |
| 2005 | "The Population prevalence of ten mtDNA mutations" | Principal Investigator Grant | Patrick F. Chinnery | University of Newcaslte upon Tyne, UK | UK | $162,878.00 | |
| 2005 | "Diagnostic Utility of DHPLC in Mitochondrial Disease" | Principal Investigator Grant | Richard H. Haas | University of California, San Diego | US | $109,991.00 | |
| 2005 | "Barth Syndrome: A Mitochondrial Disease with Insights into Cardiolipin Synthesis" | Principal Investigator Grant | Tal Mia Lewin | University of North Carolina, Chapel Hill | US | $70,625.00 | |
| 2006 | "High throughput screening for mitochondrial enhancers" | Principal Investigator Grant | Brian H. Robinson | Hospital for Sick Children | CA | $125,000.00 | |
| 2006 | "Defective biogenesis of mitochondrial beta-barrel proteins as a cause for Mohr-Tranebjaerg syndrome" | Principal Investigator Grant | Doron Rapaport | University of Tuebingen | DE | $98,000.00 | |
| 2006 | "Mechanisms of muscle dysfunction studied in mouse models of mitochondrial myopathies" | Principal Investigator Grant | Hkan Westerblad | Karolinska Institute | SE | $122,720.00 | |
| 2006 | "Enzymereplacement therapy: A novel approach for treating a mitochondrial disease-LAD deficiency" | Principal Investigator Grant | Haya Lorberboum-Galski | Hebrew University of Jerusalem | IS | $115,000.00 | |
| 2006 | "Enzymatic, assembly and genetic studies on the human pyruvate dehydrogenase multi-enzyme complex" | Principal Investigator Grant | John Gordon Lindsay | University of Glasgow | UK | $43,494.00 | |
| 2006 | "Developing therapies for mitochondrial disease" | Principal Investigator Grant | Michael J. Palladino | University of Pittsburgh | US | $98,457.00 | |
| 2006 | "Utilization of fission yeast as a model for mitochondrial morphology: a new approach to discover novel genes involved in animal cells" | Principal Investigator Grant | Stephane Chiron | University of California-San Diego | US | $98,500.00 | |
| 2006 | "Mitochondrial ribosomal proteins: candidate genes for mitochondrial disease" | Principal Investigator Grant | Thomas W. O'Brien | University of Florida | US | $125,000.00 | |
| 2006 | "Molecular signatures of mitochondrial disorders" | Principal Investigator Grant | Vishal Gohil | Massachusetts General Hospital | US | $88,850.00 | |
| 2006 | "Animal models of human Barth syndrome, a mitochondrial cardiolipin disorder" | Principal Investigator Grant | Zaza Khuchua | Vanderbilt University Medical Center | US | $110,000.00 | |
| 2007 | "Mitochondrial DNA synthesis and Krebs (tricarboxylic acid) cycle: the succinyl-CoA synthase." | Principal Investigator Grant | Ann Saada | Hadassah Hebrew University Medical Center | IS | $98,340.00 | |
| 2007 | "Mutant Complex I inÿDrosophila melanogaster: a Novel Genetic Model for Mitochondrial Disease." | Principal Investigator Grant | Brett Graham | Baylor College of Medicine | US | $111,779.00 | |
| 2007 | "Development of high throughput mtDNA sequencing for mutation detection and heteroplasmy assessment." | Principal Investigator Grant | Konstantin Khrapko | Beth Israel Deaconess Medical Center | US | $110,000.00 | |
| 2007 | "Determination of the nuclear transcriptional responses that affect animal physiopathology upon impaired mitochondrial respiratory chain function." | Principal Investigator Grant | Ludivine Walter | Cornell University | US | $100,000.00 | |
| 2007 | "Development of high throughput assays for mitochondrial respiratory chain function." | Principal Investigator Grant | Michael Paul King | Thomas Jefferson University | US | $118,648.00 | |
| 2007 | "Genotype-Phenotype Correlation and Genetic Modifiers in Barth Syndrome."ÿ | Principal Investigator Grant | Mindong Ren | New York University School of Medicine | US | $157,450.00 | |
| 2007 | "Identification of novel genes associated with isolated complex I deficiency using whole genome mapping in small consanguineous families" | Principal Investigator Grant | Orly Elpeleg | Hadassah Hebrew University Medical Center | IS | $60,500.00 | |
| 2007 | "Mitochondrial calcium signaling and organelle dysfunction in mitochondrial diseases: molecularÿdeterminants and regulatory mechanisms." | Principal Investigator Grant | Paolo Pinton | University of Ferrara | IT | $86,250.00 | |
| 2007 | "Molecular genetic dissection of mitochondrial complex I assembly" | Principal Investigator Grant | Patrice Hamel | Ohio State University | US | $114,189.00 | |
| 2007 | "Defining copper homeostasis in the mitochondria: Recruitment and distribution of copper for the assembly of cuproenzymes." | Principal Investigator Grant | Paul A. Cobine | University of Utah | US | $99,000.00 | |
| 2007 | "Increased mitochondrial biogenesis as therapy to mitochondrial myopathies." | Principal Investigator Grant | Tina Wenz | University of Miami | US | $94,481.00 | |
| 2008 | "Cerium oxide nanoparticles in the treatment of mitochondrial diseases." | Principal Investigator Grant | Beverly A. Rzigalinski | Virginia College of Osteopathic Medicine | US | $101,569.00 | |
| 2008 | "Identifying genetic modifiers of tissue-specific mitochondrial DNA segregation." | Principal Investigator Grant | Brendan James Battersby | University of Helsinki | FI | $150,000.00 | |
| 2008 | "Evaluation of the efficacy and safety of erythrocyte encapsulated thymidine phosphorylase therapy in two patients with mitochondrial neurogastrointestional encephalomyopathy." | Principal Investigator Grant | Bridget Elizabeth Bax | St. George's University of London | UK | $116,428.00 | |
| 2008 | "Study of redox regulated pathways in the mitochondrion." | Principal Investigator Grant | Deepa Vinay Dabir | University of California-Los Angeles | US | $100,000.00 | |
| 2008 | "Mitochondrial Fusion Defects in Neurological Disease." | Principal Investigator Grant | Elizabeth Anne Amiott | University of Utah | US | $98,300.00 | |
| 2008 | "The role of the PINK1/Parkin pathway in mitochondrial integrity." | Principal Investigator Grant | Leo Joseph Pallanck | University of Washington | US | $125,000.00 | |
| 2008 | "OXPHOS modulation by mitochondrial protein phosphorylation in mtDNA mutant cells." | Principal Investigator Grant | Rebeca Acin-Peres | Weill Medical College, Cornell University | US | $99,990.00 | |
| 2008 | "Evaluation of novel zinc finger nucleases as a means to target m.3243A>G in vivo." | Principal Investigator Grant | Sion L. Williams | University of Miami | US | $99,998.00 | |
| 2008 | "Utilization of knockout mouse models to elucidate the importance of the de novo mitochondrial fatty acid synthesis pathway in mitochondrial function." | Principal Investigator Grant | Stuart Smith | Children's Hospital & Research Institute at Oakland | US | $128,563.00 | |
| 2008 | "Selective alteration of mitochondrial gene expression via modulation of the dual-function h-mtTFB1 and B2 factors as a potential therapy for mitochondrial diseases." | Principal Investigator Grant | Timothy E. Shutt | Yale University School of Medicine | US | $99,998.00 | |
| 2009 | "Mitochondrial dysfunction, exercise intolerance and myopathy in skeletal muscle-specific PGC-1à-deficient mice." | Principal Investigator Grant | Christoph Handschin | University of Basel | SE | $130,000.00 | |
| 2009 | "Development of a Novel Mass Spectrometric Approach to Measure Mitochondrial Oxidative DamageÿIn Vivo." | Principal Investigator Grant | Michael P. Murphy | Medical Research Council, Dunn Human Nutrition Unit | UK | $110,000.00 | |
| 2009 | "Selecting for Transformation with Mitochondrial DNA." | Principal Investigator Grant | Patrick H. O'Farrell | University of California-San Francisco | US | $81,857.00 | |
| 2009 | "Investigating the Rescue of Mitochondrial Dysfunction by SIRT1 and Calorie Restriction." | Principal Investigator Grant | Sarika Srivastava | Harvard Medical School | US | $90,804.00 | |
| 2010 | "Spinocerebellar ataxia with axonal neuropathy: defining the mitochondrial component." | Principal Investigator Grant | Cornelius Franciscus Boerkoel | University of British Columbia | CA | $130,348.00 | |
| 2010 | "Pilot study to investigate the efficacy of L-arginine therapy on endothelium-dependent vasodilation & mitochondrial metabolism in MELAS syndrome." | Principal Investigator Grant | Ingrid Tein | Hospital for Sick Children | CA | $75,000.00 | |
| 2010 | "DMCA and Barth Syndromes- similar diseases caused by defects in mitochondrial protein import?" | Principal Investigator Grant | Robert E. Jensen | Johns Hopkins University | US | $110,000.00 | |
| 2011 | "Regulatory mechanisms governing TFAM-mediated mtDNA copy number control" | Principal Investigator Grant | Brett Kaufman | University of Pennsylvania | US | $120,000.00 | |
| 2011 | "Deficiencies of tRNA maturation and the pathogenesis of mitochondrial diseases." | Principal Investigator Grant | Miguel Garcia-Diaz | Stony Brook University | US | $100,000.00 | |
| 2011 | "Therapeutic Interventions for Pyruvate Dehydrogenase Deficiency." | Principal Investigator Grant | Nicola Brunetti-Pierri | Telethon Institute of Genetics and MedicineÿFondazione Telethon | IT | $120,000.00 | |
| 2011 | "Driving Selection Against Heteroplasmic Mitochondrial DNA Mutations by Enhancing Mitophagy." | Principal Investigator Grant | Ying Dai | Beth Israel Deaconess Medical Center | US | $80,000.00 | |
| 2012 | "Estrogen mediated regulation of mitochondrial biogenesis and functions: possible therapeutic implications for Leber's hereditary optic neuropathy." | Principal Investigator Grant | Carla Giordano | University of Rome | IT | $108,000.00 | |
| 2012 | "Ultra-high-throughput screening for mitochondrial enhancers as novel targets for treating mitochondrial diseases." | Principal Investigator Grant | David A. Sinclair | Harvard Medical School | US | $80,000.00 | |
| 2012 | "Preclinical studies for the gene therapy of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Long-term follow-up and use of adeno-associated viral vectors." | Principal Investigator Grant | Javier Torres-Torronteras | Vall d'Hebron Research Institute | ES | $93,000.00 | |
| 2012 | "Rescuing complex I defective mitochondria and target organs with methylene blue." | Principal Investigator Grant | Mariana G. Rosca | Case Western Reserve University | US | $100,000.00 | |
| 2012 | "Mechanisms and treatment of mitochondrial deafness." | Principal Investigator Grant | Nuno Raimundo | Yale University School of Medicine | US | $50,000.00 | |
| 2012 | "Multifunctional Radical Quenchers (MRQs) for the Treatment of Mitochondrial Disorders- Evaluation in Cellular Disease Models" | Principal Investigator Grant | Sidney M. Hecht | Arizona State University Center for BioEnergetics | US | $105,293.00 | |
| 2012 | "Multifunctional Radical Quenchers (MRQs) for the Treatment of Mitochondrial Disorders- Exploration of the MRQ B Series" | Principal Investigator Grant | Sidney M. Hecht | Arizona State University, Center for BioEnergetics | US | $102,836.00 | |
| 2012 | "Testing Gene Therapy in an Animal Model of Mitochondrial Respiratory Chain Disorders." | Principal Investigator Grant | William James Craigen | Baylor College of Medicine | US | $100,000.00 | |
| 2012-2023 | Mitochondrial Disease Sequence Data Resource Consortium | Infrastructure Grant | Marni Falk | Children's Hospital of Philadelphia | US | $288,000.00 | |
| 2012-2023 | North American Mitochondrial Disease Consortium | Infrastructure Grant | Michio Hirano | Columbia University | US | $300,000.00 | |
| 2013 | "A Genome-wide RNAi Screening to Identify New Genes Involved in Mitochondrial Diseases." | Principal Investigator Grant | Alberto Sanz-Monterro | University of Tampere | FI | $100,000.00 | |
| 2013 | "Hypogonadotropic hypogonadism in mitochondrial disease: prevalence, phenotypic heterogeneity and hormonal spectrum variations in a tertiary hospital cohort." | Clinical Fellowship Training Grant | Amel Karaa | Harvard Medical School and Massachusetts General Hospital | US | $70,000.00 | |
| 2013 | "Characterization of disease-specific mitochondrial stress-signaling pathways in vivoas potential therapeutic targets for mitochondrial diseases." | Principal Investigator Grant | Gerald Shadel | Yale University | US | $90,000.00 | |
| 2013 | "Using mtDNA mutator mouse-derived lineages to generate mouse models of human mitochondrial diseases." | Principal Investigator Grant | James Stewart | Max Planck Institute for the Biology of Ageing | DE | $90,000.00 | |
| 2013 | "Utilizing dynamically regulated phosphorylation as a means to modulate mitochondrial metabolism." | Postdoctoral Fellow Grant | Natalie Niemi | University of Wisconsin | US | $75,000.00 | |
| 2013 | "A Human Reprogrammed-Cell Model of MELAS." | Principal Investigator Grant | Rajesh Ambasudhan | Sanford-Burnham Medical Research Institute | US | $84,000.00 | |
| 2014 | "Developing specific mitochondrial nucleases to eliminate mutant mtDNA." | Principal Investigator Grant | Carlos Moraes | University of Miami Miller School of Medicine | US | $120,000.00 | |
| 2014 | "Pathogenesis of myopathies caused by mitochondrial phosphate carrier mutations." | Principal Investigator Grant | Erin Seifert | Thomas Jefferson University | US | $120,000.00 | |
| 2014 | "Modulation of GSK3 activity to maintain neuronal survival in complex IV deficient mouse." | Principal Investigator Grant | Francisca Diaz | University of Miami Miller School of Medicine | US | $80,000.00 | |
| 2014 | "Development of an autologous myogenic stem cell therapy for carriers of a heteroplasmic mtDNA mutation, a proof of principle study."ÿ | Principal Investigator Grant | Hubert Smeets | Maastricht University | NE | $25,000.00 | |
| 2014 | "Improving CNS delivery of brain antioxidants after acute metabolic decompensation in mitochondrial disease."ÿ | Principal Investigator Grant | Michael James Bell | University of Pittsburgh | US | $23,679.00 | |
| 2014 | "Targeted delivery of copper to mitochondria: investigating its therapeutic potential for the effective treatment of patients with mutations in SCO1 and SCO2."ÿÿ | Principal Investigator Grant | Scot Leary | University of Saskatchewan | CA | $120,000.00 | |
| 2015 | "Vitamins B as Therapy for Disorders with mtDNA Instability."ÿ | Principal Investigator Grant | Anu Suomalainen Wartiovaara | University of Helsinki | FI | $100,000.00 | |
| 2015 | "Kinetics of Mitochondrial Complex Assembly."ÿ | Principal Investigator Grant | Daniel F. Bogenhagen | Stony Brook University | US | $100,000.00 | |
| 2015 | "Allotopic RNA Rescue of LHON Mouse Model." | Postdoctoral Fellow Grant | Atif Towheed | Children's Hospital of Philadelphia | US | $70,000.00 | |
| 2015 | "Utility of FGF21 and GDF15 as Diagnostic and Prognostic Biomarkersof Mitochondrial Respiratory Chain Disorders."ÿ | Principal Investigator Grant | John Christodoulou | Children's Hospital at Westmead | AU | $140,000.00 | Mito Foundation |
| 2015 | "Validation of an Observer Reported Outcome (ObsRO) Measure of Home Functionality in Children with Pyruvate Dehydrogenase Complex Deficiency (PDCD)."ÿ | Principal Investigator Grant | Peter W. Stacpoole | University of Florida | US | $24,898.00 | |
| 2015 | "Characterizing the Function of the Atypical Mitochondrial Kinase ADCK3." | Principal Investigator Grant | Sara M. Nowinski | University of Utah | US | $70,000.00 | |
| 2016 | "Quality Control of Unimported Mitochondrial Precursor Proteins" | Principal Investigator Grant | Adam Hughes | University of Utah School of Medicine | US | $100,000.00 | |
| 2016 | "Molecular Mechanisms for Suppression of Mitochondrial Disease by Acarbose" | Postdoctoral Fellow Grant | Alessandro Bitto | University of Washington Medical Center | US | $70,000.00 | |
| 2016 | "Investigating the Pathogenesis of C12orf65 Deficiency in Mitochondrial Translation and Mitochondrial Disease" | Principal Investigator Grant | Brendan J. Battersby | University of Helsinki | FI | $70,000.00 | |
| 2016 | "Cerebral Folate Deficiency" | Principal Investigator Grant | William A. Gahl | National Human Genome Research Institute | US | $54,500.00 | |
| 2016 | "Interrogating the Mitochondrial Interactome Using BioID" | Principal Investigator Grant | Eric A. Shoubridge | McGill University | CA | $75,000.00 | |
| 2016 | "Manipulating the Permeability Transition Pore to Ameliorate Neonatal Heart Failure" | Principal Investigator Grant | George A. Porter, Jr. | University of Rochester Medical Center | US | $115,042.00 | |
| 2016 | "Mitochondrial Complexome Profiling Provides a Novel Tool to Diagnose and Understand Complex I Deficiency" | Principal Investigator Grant | Leo Nijtmans | Radboud University Medical Centre | NL | $40,000.00 | |
| 2016 | "Phenylbutyrate Therapy for Pyruvate Dehydrogenase Deficiency" | Principal Investigator Grant | Nicola Brunetti-Pierri | Telethon Institute of Genetics and Medicine | IT | $25,000.00 | |
| 2016 | "Development and Validation of a New Outcome Measure in Mitochondrial Disease" | Principal Investigator Grant | Zarazuela Zolkipli Cunningham | Children's Hospital of Philadelphia | US | $25,000.00 | |
| 2017 | "Developing personalized mitochondrial disease treatment for SURF1 disease patients by modeling effects of candidate therapies in human patient cell and zebrafish animal models" | Principal Investigator Grant | Marni Falk | Children's Hospital of Philadelphia | US | $25,450.00 | |
| 2017 | "A Single Blood Draw Test of Mitochondrial Disease" | Postdoctoral Fellow Grant | Melissa Anne Walker | Massachusetts General Hospital | US | $100,000.00 | |
| 2017 | Identification of SLC Family Members as Predictive Biomarkers for Mitochondrial Disease" | Principal Investigator Grant | Prashant Mishra | University of Texas Southwestern Medical Center; Children's Research Institute | US | $100,000.00 | |
| 2017 | "Photopic Negative Response as an Objective Biomarker in Mitochondrial Disease" | Principal Investigator Grant | Rustum Karanjia | University of Ottawa | CA | $100,000.00 | |
| 2017 | "Study of Mouse Models of Mitochondrial Optic Neuropathies" | Principal Investigator Grant | Alfredo Sadun | Doheny Eye Institute | US | $25,000.00 | |
| 2017 | "LHON Mood Study" | Principal Investigator Grant | Alfredo Sadun | Doheny Eye Institute | US | $25,000.00 | |
| 2017 | "Pearson Syndrome Natrual History Study - Travel Funds Grant" | Principal Investigator Grant | Sumit Parikh | Cleveland Clinic | US | $5,000.00 | |
| 2018 | Leigh Syndrome - Leigh Syndrome Roadmap Project Consortium Funding | LSIC Roadmap Project Grant | International | $1,090,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon | ||
| 2019 | "Identification of novel compounds to treat rare mitochondrial diseases" | Postdoctoral Fellow Grant - accelerators | Arwen Gao | EPFL - Lab of Integrative Systems Physiology | CH | $50,000.00 | |
| 2019 | "Structural and Functional Characterization of COQ9 in Facilitating Coenzyme Q Biosynthesis and Complex Q Formation" | Postdoctoral Fellow Grant - accelerators - Family Funded | Rachel Guerra | Morgridge Institute for Research | US | $50,000.00 | |
| 2019 | "Manipulating Mitochondrial Metabolism Via The Mitochondrial Derived Compartment Pathway" | Postdoctoral Fellow Grant - accelerators - Family Funded | Zachary Wilson | University of Utah | US | $50,000.00 | |
| 2019 | "Can novel mitochondria-targeted hydrogen sulfide delivery molecules restore cellular bioenergetics in primary mitochondrial disease?" | Principal Investigator Grant | Matthew Whiteman | University of Exeter | UK | $200,000.00 | |
| 2019 | "Fumarates for Leigh Syndrome" | LSIC Roadmap Project Grant | Gino Cortopassi | University of California, Davis | US | $30,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2019 | "The role of microglia, NAD+ and mitochondrial ROS in Leigh Syndrome" | LSIC Roadmap Project Grant | Dao-Fu Dai | Unveristy of Iowa | US | $15,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2019 | "Therapeutic efficacy of miR-181a/b down regulation in Leigh Syndrome | LSIC Roadmap Project Grant | Brunella Franco | Fondazione Telethon | IT | $25,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2019 | "Novel dietary and pharmacological therapies in a Drosophila model of Maternally Inherited Leigh Syndrome" | LSIC Roadmap Project Grant | Michael Palladino | University of Pittsburgh | US | $50,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2019 | "iPSC-driven repositioning of PDE5 inhibitors for Leigh Syndrome patients carrying MT-ATP6 mutations" | LSIC Roadmap Project Grant | Alessandro Prigione | Heinrich Heine University | DE | $34,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2019 | "Leigh syndrome: Investigating outcome measure & natural history (LION) - a prospective, longitudinal cohort study" | LSIC Roadmap Project Grant | Robert McFarland, PhD | Newcastle University | UK | $50,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2019 | "Natural History of Mitochondrial Myopathy" | Principal Investigator Grant | Zarazuela Zolkipli Cunningham | Children's Hospital of Philadelphia | US | $100,000.00 | |
| 2020 | "Development of Therapeutic Models for MECR-Related Disease" | Family Impact Fund Grant | Deborah Murdock | Children's Hospital of Philadelphia | US | $199,710.00 | |
| 2020 | "Mechanisms of protein assembly underlying mitochondrial DNA maintenance but altered in early-onset neurodegenerative disorders" | Principal Investigator Grant | Breann Brown | Vanderbilt University | US | $100,000.00 | |
| 2020 | "Implementation of the CRISPR gene editing technology Plasmids - toward the curing of mitochondrial diseases caused by mutations in mitochondrial DNA" | Principal Investigator Grant | Hajime Sakai | NAPIGEN | US | $100,000.00 | |
| 2020 | "Investigating intrinsic and extrinsic factors influencing mitochondrial heteroplasmy in mt-tRNA mutation-linked disease" | Postdoctoral Fellow Grant - accelerators | Kinsley Bell | Stanford University | US | $50,000.00 | |
| 2020 | "Effect of Putative Therapeutic Interventions on Cultured Skin Fibroblasts from Patients with Identified Pathological Mutations for Mitochondrial Disease" | Gateway to Mitochondrial Medicine Grant Grant | Julia Stokes | Seattle Children's Hospital | US | $5,000.00 | NAMDC |
| 2020 | "An ATP synthesis assay to evaluate genetic variants in complex V" | Gateway to Mitochondrial Medicine Grant | Kaz M. Knight | University of Colorado Anschultz | US | $5,000.00 | NAMDC |
| 2020 | "Impact of COVID-19 on People Living with Rare Disease and Their Families" | Gateway to Mitochondrial Medicine Grant | Kevin Wongsodirdjo | Columbia University | US | $5,000.00 | NAMDC |
| 2020 | "Effect of Putative Therapeutic Interventions on Cultured Skin Fibroblasts from Patients with Identified Pathological Mutations for Mitochondrial Disease" | Gateway to Mitochondrial Medicine Grant | Lilly Izaelia Lee | University of California San Diego | US | $5,000.00 | NAMDC |
| 2020 | "Determination of disease-causing variant frequencies in genes associated with pyruvate dehydrogenase deficiency" | Gateway to Mitochondrial Medicine Grant | Nikki Ducich | University Hospitals Cleveland Medical Center | US | $5,000.00 | NAMDC |
| 2020 | "Intellectual disability and mitochondrial disease: A cohort study" | Gateway to Mitochondrial Medicine Grant | Rory Tinker | Children's Hospital of Philadelphia | US | $5,000.00 | NAMDC |
| 2021 | Deletion Syndrome Roadmap Project | Family Impact Fund Grant | Samantha Lewis | University of California - Berkeley | US | $50,000.00 | |
| 2021 | "Modulation of the nuclear epigenome as a new strategy for mitochondrial DNA heteroplasmy shift" | Postdoctoral Fellow Grant - accelerators | Lia Mayorga | Instituto de Histolgoia y Embriologia de Mendoza (IHEM) | AR | $50,000.00 | |
| 2021 | "ATPIF1 Expression in Mitochondrial Disease" | Gateway to Mitochondrial Medicine Grant | Dana Strode | University of Colorado | US | $5,000.00 | NAMDC |
| 2021 | "Efficacy of Exercise in Patients with Mitochondrial Myopathy" | Gateway to Mitochondrial Medicine Grant | Isaac T. Martin | Children's Hospital of Philadelphia | US | $5,000.00 | NAMDC |
| 2021 | "Improving emergency care for mitochondrial patients" | Gateway to Mitochondrial Medicine Grant | Jennifer Yang | University of California San Diego | US | $5,000.00 | NAMDC |
| 2021 | "Developing novel therapeutics for Leber Hereditary Optic Neuropathy (LHON) and utilizing in vitro models" | Gateway to Mitochondrial Medicine Grant | Joshua P. Nederveen | McMaster University | CA | $5,000.00 | NAMDC |
| 2021 | "Development of a single-chain mitochondrial base editor" | Gateway to Mitochondrial Medicine Grant | Santiago Restrepo-Castillo | MAYO Clinic | US | $5,000.00 | NAMDC |
| 2021 | "Time to harmonize mitochondrial syndromes classification: a consensus from the North American Mitochondrial Disease Consortium (NAMDC)" | Gateway to Mitochondrial Medicine Grant | Valentina Emmanuele | Columbia University | US | $5,000.00 | NAMDC |
| 2021 | "Combining gene replacement and focused ultrasound to treat Leigh Syndrome" | LSIC Roadmap Project Grant | Michael Decressac | Universite Grenoble-Alpes | FR | $30,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2021 | "Induced Pluripotent stem cells (iPSC)-driven drug repositioning for Leigh Syndrome" | LSIC Roadmap Project Grant | Alessandro Prigione/Dao-Fu Dai | Heinrich Heine University/University of Iowa | DE | $40,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2021 | "Gene therapy in mouse models of Leigh Syndrome" | LSIC Roadmap Project Grant | Massimo Zeviani | University of Padova | IT | $50,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2021 | "Using a variety of pre-clinical disease motels to identify novel drug candidates for the treatment of Leigh Syndrome" | LSIC Roadmap Project Grant | Roan Louw | North-West University | ZA | $8,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2021 | "Safety, Efficacy and Mechanism of a Nicotinamidated Fumarate for Leigh Syndrome" | LSIC Roadmap Project Grant | Gino Cortopassi | University of California - Davis | US | $22,000.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |
| 2022 | "Exploring the etiologies of multiple low level mitochondrial DNA deletions in muscle tissues" | Family Impact Fund Grant | Jing Wang | Children's Hospital of Philadelphia | US | $100,000.00 | |
| 2022 | "Pre-clinical study on novel treatment strategies for RRM2B disease" | Postdoctoral Fellow Grant - accelerators | Sara Carli | Universita di Bologna | IT | $50,000.00 | |
| 2022 | "Generation of innovative gene-independent therapeutic strategies for mitochondrial optic neuropathies (MONs)" | Postdoctoral Fellow Grant | Filomena Massa | Telethon Institute of Genetics and Medicine | IT | $50,000.00 | |
| 2022 | "Interrogating cell death mechanisms and identifying therapeutic leads in zebrafish surf1-/- models of Leigh syndrome" | Postdoctoral Fellow Grant | Leonard Berg | Children's Hospital of Philadelphia | US | $50,000.00 | |
| 2022 | "A reference guide for functional mitochondrial analyses, a new tool in the mitochondrial disease diagnosis repertoire" | Gateway to Mitochondrial Medicine Grant | Laura Teresa Forero Zapata | University of California San Diego | US | $5,000.00 | NAMDC |
| 2022 | "Dysmorphology in Mitochondrial Disease" | Gateway to Mitochondrial Medicine Grant | Mary Higgins | Children's Hospital of Philadelphia | US | $5,000.00 | NAMDC |
| 2022 | "Characterization of a novel MT-TL1 pathogenic variant causing late-onset chronic progressive external opthalmoplegia-plus" | Gateway to Mitochondrial Medicine Grant | Amber Tucker | Columbia University | US | $7,500.00 | NAMDC |
| 2022 | "Metabolism and Epigenetics of Uveal Melanoma" | Gateway to Mitochondrial Medicine Grant | Piotr Kopinksi | MAYO Clinic | US | $5,000.00 | NAMDC |
| 2022 | "Pathogenic variants in MRPS18C cause a complex mitochondrial neurocardiac disorder" | Gateway to Mitochondrial Medicine Grant | Jessica Lee | University of Colorado | US | $5,000.00 | NAMDC |
| 2022 | "Harnessing the potential of transcriptional adaptation for patients with rare mitochondrial gentic disorders" | Gateway to Mitochondrial Medicine Grant | Adriana Morales Gomez | MAYO Clinic | US | $5,000.00 | NAMDC |
| 2022 | "Understanding the impact of SARS-CoV-2 on leukocyte mitochondrial function in MELAS patients and healthy, sex- and age matched controls." | Gateway to Mitochondrial Medicine Grant | Donald Xhuti | McMaster University | CA | $7,500.00 | NAMDC |
| 2022 | "Understanding the impact of SARS-CoV-2 on leukocyte mitochondrial function in MELAS patients and healthy, sex- and age matched controls." | Gateway to Mitochondrial Medicine Grant | Joshua P. Nederveen | McMaster University | CA | $5,000.00 | NAMDC |
| 2023 | Leigh Syndrome - LSRP Natural History Study | LSIC Roadmap Project Grant | Children's Hospital of Philadelphia, UTHealth Houston, Akron Children's Hospital and University of California - San Diego | US | $97,339.00 | Mito Foundation, Lily Foundation, PALS, MitoCon | |
| 2023 | Digital Video Assessment for PolG/PMM Patients | Infrastructure Grant | Casimir/Emmes | US | $200,000.00 | POLG Foundation, Mito Foundation | |
| 2023 | Perlara Leigh Syndrome Roadmap Project | Family Impact Fund Grant | Ethan Perlstein | Perlara | US | $72,500.00 | |
| 2023 | "The role of microglia in AIFM1-associated mitochondrial disease" | Gateway to Mitochondrial Medicine Grant | Ryan Liao | Seattle Children's Hospital | US | $5,000.00 | NAMDC |
| 2023 | "Systematic evaluation of laboratory primary endpoints of untargeted therapeutics for pyruvate dehydrogenase complex deficiency" | Gateway to Mitochondrial Medicine Grant | Anisha Verma | University of Pittsburgh Medical Center | US | $5,000.00 | NAMDC |
| 2023 | "Resilience and coping in parents of individuals with primary mitochondrial disease: Quantitative and qualitative assessment" | Gateway to Mitochondrial Medicine Grant | Camille Brown | Penn University | US | $5,000.00 | NAMDC |
| 2023 | "Whole genome sequencing for the diagnosis of mitochondrial disease" | Gateway to Mitochondrial Medicine Grant | Mallory Owen | University of California - San Diego | US | $5,000.00 | NAMDC |
| 2023 | "Establishing Embryonic Viability in GUK1-Deficient Mouse Model through Forodesine Treatment: A Potential Therapeutic Approach" | Gateway to Mitochondrial Medicine Grant | Agustin Hidalgo-Gutierrez | Columbia University | US | $5,000.00 | NAMDC |
| 2023 | "Development of in vitro models of the pathogenic m.3242G>A variant" | Gateway to Mitochondrial Medicine Grant | Santiago Restrepo-Castillo | MAYO Clinic | US | $5,000.00 | NAMDC |
| 2023 | "Probing the Pathogenic Mechanisms of Parkinsonism-Like Features in a Novel Primary Cell Model for Leigh Syndrome" | Principal Investigator Grant | Anthony Grillo | University of Cincinnati | US | $100,000.00 | |
| 2023 | "Pilot Study of Apple Watches for Monitoring Patients with Mitochondrial Disease." | Clinical Trial Readiness Grant | Zarazuela Zolkipli-Cunningham | Children's Hospital of Philadelphia | US | $100,000.00 | |
| 2023 | "The Role of Metaxins in Mitochondrial Health and Homeostasis" | Postdoctoral Fellow Grant - Family Funded | Jonathan Dietz | Waksman Institute - Rutgers | US | $50,000.00 | |
| 2023 | "Mitochondrial ribosome signaling and survival mechanisms in mitochondrial disease" | Postdoctoral Fellow Grant - accelerators | Conor Ronayne/Jonathan Palozzi | Dana Farber Cancer Institute | US | $50,000.00 | |
| 2023 | "Leveraging a preclinical animal model to repurpose FDA approved drugs for mtDNA depletion syndromes" | Postdoctoral Fellow Grant - Family Funded | Tejashree Waingankar | University of California - Berkeley | US | $50,000.00 | |
| 2023 | "Studies toward repurposing drugs to treat mitochondrial disease patients with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS)" | Family Fund Impact Grant | Tamas Kozicz | Mount Sinai | US | $106,000.00 | |
| 2024 | "Research toward the development of therapies for MEPAN" | Family Fund Impact Grant | Deborah Murdock | Children's Hospital of Philadelphia | US | $450,000.00 | |
| 2024 | "Single Large-Scale mtDNA Deletion (SLSMD) Syndrome Research Program" | Family Fund Impact Grant | Suraiya Haroon | Children's Hospital of Philadelphia | US | $200,000.00 | |
| 2024 | "POLG- Project Butterfly" | Family Fund Impact Grant | Michio Hirano | Columbia University | US | $23,000.00 | |
| 2024 | "Prevalence of Primary Mitochondrial and Metabolic Disorders in the Nephrotic Syndrome Study Network" | Gateway to Mitochondrial Medicine Grant | Daniel Schecter | Mount Sinai | US | $5,000.00 | NAMDC |
| 2024 | "Evaulating the role of mitophagy in muscle cell differentiation and regeneration oin an iPSC-derived skeletal muscle model of Barth Syndrome" | Gateway to Mitochondrial Medicine Grant | Olivia Sniezek Carney | University of Pittsburgh | US | $5,000.00 | NAMDC |
| 2024 | "Clinical presentations of Primary Hyperoxaluria 3 in pediatric and adult HOGA1 carrier populations" | Gateway to Mitochondrial Medicine Grant | Sohum Purao | Baylor College of Medicine | US | $5,000.00 | NAMDC |
| 2024 | "Prospective analysis of UPMC patients with specific amino acids ratios to identify those with pyruvate dehydrogenase deficiency or other mitochondrial diseases" | Gateway to Mitochondrial Medicine Grant | Bianca Seminotti | Children's Hospital Pittsburgh | US | $5,000.00 | NAMDC |
| 2024 | "Exploring the role of platelet/plasma mitochondria delivery in mitochondrial diseases: A Potential Therapeutic Approach" | Gateway to Mitochondrial Medicine Grant | Jieru Egeria Lin | Columbia University | US | $5,000.00 | NAMDC |
| 2024 | "Assessing Neurodevelopmental Outcomes in Mitochondrial Disease" | Gateway to Mitochondrial Medicine Grant | Fatima Alkhyeli | UC San Diego | US | $5,000.00 | NAMDC |
| 2024 | "Utilizing long-read sequencing to decipher the genomic architecture of Early-Onset Parkinson's Disease, a mitochondrial disease" | Gateway to Mitochondrial Medicine Grant | Ngan Tran | Mayo Clinic | US | $5,000.00 | NAMDC |
| 2024 | "Elucidating mechanisms of cycloheximide to treat primary mitochondrial respiratory chain disease" | Gateway to Mitochondrial Medicine Grant | Shrey Dalwadi | Children's Hospital of Philadelphia | US | $5,000.00 | NAMDC |
| 2024 | "Antisense Oligonucleotides for Splice Sorrection in Mitochondrial Disorders" | Principal Investigator Grant | Holger Prokisch | Technical University of Munich | DE | $100,000.00 | |
| 2024 | "Dysregulation of MTORC1 in human cell models of Mitochondrial Complex V deficiency" | Postdoctoral Fellow Grant - accelerators | Kristen G. Navarro | Children's Hospital of Philadelphia | US | $50,000.00 | |
| 2024 | "Implications and Novel Therapeutic Insights on Mitochondrial Integrity in Hematopoiesis and Immune Balance in the context of Mitochondrial Diseases" | Postdoctoral Fellow Grant - Family Funded | Raquel Justo-Mendez | IRB Barcelona | ES | $50,000.00 | |
| 2024 | "Unveiling the Role of Secreted Mitochondria in Extracellular Vesicles: Implications for Primary Mitochondrial Diseases" | Postdoctoral Fellow Grant - Family Funded | Daniel Lagos | University of Cambridge | GB | $50,000.00 | |
| 2024 | Leigh Syndrome - LSRP Natural History Study | LSIC Roadmap Project Grant | Children's Hospital of Philadelphia, UTHealth Houston, Akron Children's Hospital and University of California - San Diego, Murdoch Children's Research Institute | US | $84,443.00 | Mito Foundation, Lily Foundation, PALS, MitoCon | |
| 2025 | "NanoMDS ? Nanomedicines nucleotides or RNA therapeutics delivery for treating mitochondrial DNA depletion syndromes" | Principal Investigator Grant | Caterina Garone | University of Bologna | IT | $100,000.00 | Mito Foundation |
| 2025 | "Elucidating Mitochondrial Impairment in Troyer Syndrome - EMITS" | Principal Investigator Grant | Christian Bergamini | University of Bologna | IT | $100,000.00 | Mito Foundation |
| 2025 | "Unraveling the Effects of SSBP1 Mutation on Vision" | Principal Investigator Grant | Nan-Kai Wong | Columbia University | US | $100,000.00 | Mito Foundation |
| 2025 | "Anaplerotic odd-chain fatty acid therapy for the treatment of Leigh Syndrome" | Principal Principal Investigator Grant | Norma FrizzelL | University of South Carolina | US | $100,000.00 | Mito Foundation |
| 2025 | "Validating Digital Functional Assessments in Mitochondrial Diseases: A Multinational Smartphone and Wearable Validation Study" | Clinical Trial Readiness Grant | Nikita Konstantinoskiy | Jellyfish Bio, Inc. | US | $50,000.00 | Mito Foundation |
| 2025 | "Optimizing cryopreservation of muscle stem cell medicinal product for direct clinical administrationin Mitochondrial Myopathy patients" | Clinical Trial Readiness Grant | Florence Van Tienen | Maastricht University | NE | $32,531.76 | Mito Foundation |
| 2025 | "Monoclonal antibody therapy for Leigh Syndrome" | Postdoctoral Fellow Grant | Anastasia Dimitriou | University of Northumbria at Newcastle | UK | $50,000.00 | Mito Foundation & Lily Foundation |
| 2025 | "Therapeutic degrader molecules targeting excessive mitophagy in FBXL4- and PPTC7- associated Mitochondrial Disease" | Postdoctoral Fellow Grant - Family Funded | Keri-Lyn Kozul | Washington University | US | $50,000.00 | |
| 2025 | Leigh Syndrome - LSRP Natural History Study | LSIC Roadmap Project Grant | Children's Hospital of Philadelphia, UTHealth Houston, Akron Children's Hospital and University of California - San Diego, Murdoch Children's Research Institute | US | $81,797.00 | Mito Foundation, Lily Foundation, PALS, MitoCon | |
| 2026 | "A precision medicine approach targeting cardiovascular manifestations of m.3243A>G borne primary mitochondrial disease" | Graduate Student Grant | Lily Farmerie | University of Pittsburgh | US | $25,000.00 | Mito Foundation |
| 2026 | "mRNA-induced protein replacement therapy for mitochondrial DNA depletion syndromes" | Graduate Student Grant | Nissa Carrodus | The University of Queensland | AU | $25,000.00 | Mito Foundation |
| 2026 | "OPERA (OPA1-Related Energetics Rescue): Translational Validation of 20 Therapeutic Candidates in OPA1 Patient-Derived Retinal Ganglion Cells" | Postdoctoral Fellow Grant | Melis Kose | Children's Hospital of Philadelphia | US | $50,000.00 | Mito Foundation |
| 2026 | "Early Pharmacological Intervention in SURF1-Related Leigh Syndrome Using Sildenafil" | Postdoctoral Fellow Grant | Chiaro Guarona | Fondazione IRCCS Carlo Besto | IT | $50,000.00 | Mito Foundation |
| 2026 | "Function and regulation of the mitochondrial disease-causing metabolite transporter SLC25A19" | Postdoctoral Fellow Grant | Alvaro J. Narbona-Perez | University of Utah | US | $50,000.00 | Mito Foundation |
| 2026 | "Gene therapy in a humanized Dars2 mouse model that recapitulates LBSL neuropathology" | Principal Investigator Grant | Javier Tri¤anes Ramos | Amsterdam Medical Center | NE | $100,000.00 | Mito Foundation |
| 2026 | "Development of regulatable mitoTALENs to increase the efficacy of mitochondrial replacement therapy." | Principal Investigator Grant | Mary Herbert | Monash University | AU | $100,000.00 | Mito Foundation |
| 2026 | "Next-Generation Mitochondrial ND4 Gene Therapy for LHON: Improving Delivery and Mitochondrial Targeting" | Principal Investigator Grant | Jiang-Hui Wang | Centre for Eye Research Australia | AU | $100,000.00 | Mito Foundation |
| 2026 | "Elucidating the Metabolomic and Lipidomic Changes Underlying Mitochondrial Dysfunction in WWOX-Associated Neurodegeneration" | Gateway to Mitochondrial Medicine Grant | Ameya Walimbe | Baylor College of Medicine | US | $5,000.00 | NAMDC |
| 2026 | "Comprehensive Validation of FDA Screen Hits in a C. elegans model of FARS2 deficiency" | Gateway to Mitochondrial Medicine Grant | Aafia Ahmed | Children's Hospital of Philadelphia | US | $5,000.00 | NAMDC |
| 2026 | "Retrospective cohort study of neuroinflammatory overlap syndromes with primary mitochondrial diseases" | Gateway to Mitochondrial Medicine Grant | Samantha Mak | University of California, San Diego | US | $5,000.00 | NAMDC |
| 2026 | "Studying NAD booster forms to treat mitochondrial disorders in tissue culture" | Gateway to Mitochondrial Medicine Grant | Stephanie A. Lucas | Children's Hospital of Colorado | US | $5,000.00 | NAMDC |
| 2026 | "Defining the Spectrum of Hyperinflammatory Syndromes in Primary Mitochondrial Disease" | Gateway to Mitochondrial Medicine Grant | Daniel Brooks | Baylor College of Medicine/Texas Children's Hospital | US | $5,000.00 | NAMDC |
| 2026 | "Expanding Structure-Guided Ligand Strategies for Variant-Specific PDC Rescue" | Gateway to Mitochondrial Medicine Grant | Zeina Abdelsalam | University of Pittsburgh | US | $5,000.00 | NAMDC |
| 2026 | "Enhancing NRF2-mediated antioxidant defense to mitigate microglial dysfunction in POLG-associated neurodegeneration" | Gateway to Mitochondrial Medicine Grant | Jing Wang | University of California, San Diego | US | $5,000.00 | NAMDC |
| 2026 | "Optical Monitoring of Vascular Occlusion Response Dynamics in Patients with Mitochondrial Disease" | Gateway to Mitochondrial Medicine Grant | Zaha Shahdad | Children's Hospital of Philadelphia | US | $5,000.00 | NAMDC |
| 2026 | "Ligand-Mediated Modulation of PDC Function and Fatty Acid Oxidation in PDHA1-Related" | Gateway to Mitochondrial Medicine Grant | Anushka Singha Roy | University of Pittsburgh | US | $5,000.00 | NAMDC |
| 2026 | "Investigating mitoribosome alterations in RMND1 patients-derived fibroblast" | Gateway to Mitochondrial Medicine Grant | Alba Pesini | Columbia University Medical Center | US | $5,000.00 | NAMDC |
| 2026 | Leigh Syndrome - LSRP Natural History Study | LSIC Roadmap Project Grant | Children's Hospital of Philadelphia, UTHealth Houston, Akron Children's Hospital and University of California - San Diego, Murdoch Children's Research Institute | US | $69,237.00 | Mito Foundation, Lily Foundation, PALS, MitoCon |